Prevalence and incidence of hepatitis C virus (HCV) in hemodialysis patients: study of risk factors

Clin Nephrol. 1992 Jul;38(1):49-52.

Abstract

The prevalence of antibodies against hepatitis C virus (HCV) was assessed in 246 hemodialysis patients who attended a dialysis unit in Bari, using a recombinant enzyme immunoassay test (Abbot Lab.). Fifty-six (22.8%) sera were reactive to anti-HCV. The reactivity was confirmed in 46 specimens (18.7%) using the Abbott EIA HCV neutralization test. The anti-HCV prevalence was higher in males than in females and increased with age, duration of dialysis and number of transfusions. Moreover, a correlation between the presence of anti-HCV and the persistent increase of ALT was noted. The HCV-infection attack rate was calculated using the frozen sera collected from 1984 to 1990: the incidence of infection in the first year was 6.1%, and in following years 4.6%, 4.9%, 3.1%, 2.1% and 2.2%, respectively.

MeSH terms

  • Adult
  • Alanine Transaminase / blood
  • Blood Transfusion
  • Female
  • Hepatitis Antibodies / analysis*
  • Hepatitis C / epidemiology*
  • Hepatitis C / immunology
  • Hepatitis C / transmission
  • Humans
  • Immunoenzyme Techniques
  • Incidence
  • Italy / epidemiology
  • Kidney Failure, Chronic / therapy
  • Male
  • Prevalence
  • Renal Dialysis*
  • Risk Factors
  • Time Factors

Substances

  • Hepatitis Antibodies
  • Alanine Transaminase