Agreement of job-exposure matrix (JEM) assessed exposure and self-reported exposure among adult leukemia patients and controls in Shanghai

Am J Ind Med. 2004 Mar;45(3):281-8. doi: 10.1002/ajim.10351.


Background: Estimating a person's history of occupational exposure in case-control studies is difficult.

Methods: Percent agreement between selected self-reported occupational exposures and job-exposure matrix (JEM) exposure assessment for all participants and various subgroups of a population-based case-control interview study of 486 leukemia subjects and 502 healthy controls in Shanghai was evaluated.

Results: With JEM as the "gold standard," the sensitivities for self-reported exposures ranged from 0.75 to 0.98. However, that for pesticide exposure was 0.44 in subjects >51 years old. Self-reported exposures specificities ranged from 0.87 to 0.99. Agreement between self-reported exposures and JEM assessment was good (kappa coefficients [kappa]: 0.48-0.84). Variations in agreement for benzene exposure between males and females as well as between the direct interview and surrogate interview subgroups were observed.

Conclusions: The levels of agreement between self-report and JEM in this study suggest that self-reported exposures are a suitable method for assessing occupational exposures in this population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Benzene / toxicity
  • Case-Control Studies
  • China / epidemiology
  • Data Collection / methods*
  • Electromagnetic Fields / adverse effects
  • Female
  • Humans
  • Leukemia / epidemiology*
  • Male
  • Middle Aged
  • Occupational Exposure / statistics & numerical data*
  • Organic Chemicals / toxicity
  • Pesticides / toxicity
  • Registries
  • Sensitivity and Specificity
  • Solvents / toxicity


  • Organic Chemicals
  • Pesticides
  • Solvents
  • Benzene