Clinical evaluation of four one-week triple therapy regimens in eradicating Helicobacter pylori infection

World J Gastroenterol. 2004 Mar 1;10(5):747-9. doi: 10.3748/wjg.v10.i5.747.

Abstract

Aim: To evaluate clinical efficacy of four one-week triple therapies in eradicating Helicobacter pylori infection.

Methods: In this clinical trial, 132 patients with duodenal ulcer and chronic gastritis were randomly divided into four groups, and received treatment with OAC (omeprazole 20 mg + amoxicillin 1 000 mg + clarithromycin 250 mg), OFC (omeprazole 20 mg + furazolidone 100 mg + clarithromycin 250 mg), OFA (omeprazole 20 mg + furazolidone 100 mg + amoxicillin 1 000 mg) and OMC (omeprazole 20 mg + metronidazole 200 mg + clarithromycin 250 mg), respectively. Each drug was taken twice daily for one week. The (13)C urea breath test was carried out 4-8 weeks after treatment to determine the success of H pylori eradication.

Results: A total of 127 patients completed the treatment. The eradication rate for H pylori infection was 90.3%, 90.9%, 70.9% and 65.6%, respectively in OAC, OFC OMC and OFA groups.

Conclusion: A high eradication rate can be achieved with one-week OAC or OFC triple therapy. Thus, one-week triple therapies with OAC and OFC are recommended for Chinese patients with duodenal ulcers and chronic gastritis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amoxicillin / administration & dosage*
  • Amoxicillin / adverse effects
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / adverse effects
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / adverse effects
  • Anti-Ulcer Agents / administration & dosage*
  • Anti-Ulcer Agents / adverse effects
  • Clarithromycin / administration & dosage
  • Clarithromycin / adverse effects
  • Drug Therapy, Combination
  • Female
  • Furazolidone / administration & dosage
  • Furazolidone / adverse effects
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Male
  • Middle Aged
  • Omeprazole / administration & dosage*
  • Omeprazole / adverse effects
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local
  • Anti-Ulcer Agents
  • Furazolidone
  • Amoxicillin
  • Clarithromycin
  • Omeprazole