Chronic fatigue syndrome in adolescents: a follow-up study

Arch Pediatr Adolesc Med. 2004 Mar;158(3):225-9. doi: 10.1001/archpedi.158.3.225.


Objectives: To compare the frequency of persistent symptoms up to 8 years after illness onset in adolescents diagnosed as having chronic fatigue syndrome, idiopathic chronic fatigue, and unexplained fatigue for less than 6 months, and to determine if hospital admission is associated with outcome.

Design: A cohort study using questionnaire follow-up.

Setting: A tertiary referral hospital.

Patients: Consecutive adolescents referred for assessment of persistent fatigue were identified and retrospectively divided into 3 groups according to the diagnostic criteria for chronic fatigue syndrome and idiopathic chronic fatigue.

Intervention: A questionnaire was designed and administered by telephone at a mean of 4.57 years after the initial examination.

Main outcome measure: The persistence of self-reported symptoms was compared with respect to patient group and admission.

Results: Outcome data were obtained for 34 (69%) of the 49 eligible subjects. Twenty-five percent of the chronic fatigue syndrome group showed near to complete improvement, 31% showed partial improvement, and 44% showed no improvement. The idiopathic chronic fatigue group had near to complete recovery in 50%, partial in 10%, and no improvement in 40%. Those with unexplained fatigue for less than 6 months had all recovered. There was no difference between the outcome of the subjects admitted to the hospital and those managed as outpatients.

Conclusions: Adolescents with less than 6 months of fatigue have a good outcome. Unexplained fatigue lasting more than 6 months has a similar outcome regardless of the presence of minor criteria for chronic fatigue syndrome.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Cohort Studies
  • Fatigue Syndrome, Chronic / diagnosis*
  • Fatigue Syndrome, Chronic / therapy
  • Female
  • Follow-Up Studies
  • Hospitalization
  • Humans
  • Male
  • Retrospective Studies
  • Treatment Outcome