Pharmacology of capacitative calcium entry

Mol Interv. 2001 Jun;1(2):84-94.


The versatility of Ca(2+) as a messenger in multiple signaling events requires that the concentration of calcium ions within the cytoplasm be highly regulated. In particular, the release of calcium from intracellular stores must often be linked to calcium influx across the cell membrane. Capacitative calcium entry, whereby the depletion of intracellular Ca(2+) stores induces the influx of extracellular calcium, is a crucial element of concerted calcium signaling. Investigations into the phenomenon are contributing to a new appreciation for the organized cytoplasmic framework that supports calcium signaling.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / antagonists & inhibitors*
  • Calcium / metabolism
  • Calcium Channel Blockers / pharmacology
  • Calcium Channels
  • Calcium Signaling*
  • Cell Membrane / metabolism*
  • Cytoplasm / metabolism
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Ion Transport / physiology*
  • Models, Biological
  • Pharmacology*


  • Calcium Channel Blockers
  • Calcium Channels
  • Calcium