Apolipoprotein E, amyloid, and Alzheimer disease

Mol Interv. 2002 Oct;2(6):363-75, 339. doi: 10.1124/mi.2.6.363.


Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (apoE). The risk that specific isoforms of apoE pose with regard to Alzheimer Disease clearly varies, and so the roles that apoE plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / physiopathology*
  • Amyloid / metabolism*
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Apolipoproteins E / genetics
  • Apolipoproteins E / metabolism*
  • Central Nervous System / metabolism
  • Genetic Predisposition to Disease
  • Humans
  • Mice


  • Amyloid
  • Amyloid beta-Peptides
  • Apolipoproteins E