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Review
, 3 (3), 127-30

Aurora-A Overexpression Leads to Override of the Microtubule-Kinetochore Attachment Checkpoint

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Review

Aurora-A Overexpression Leads to Override of the Microtubule-Kinetochore Attachment Checkpoint

Stéphanie Dutertre et al. Mol Interv.

Abstract

The amplification of AURORA-A is frequently observed in specific epithelial cell malignancies. The overexpression of aurora-A, a Ser-Thr kinase known to localize to centrosomes during mitosis, appears to imbue cancerous cells with resistance to spindle-checkpoint-targeting drugs such as paclitaxel (Taxol). Indeed, a recent publication by Anand et al. indicates that overexpression of AURORA-A may interfere with spindle-microtubule attachment and disrupt the regulation of the spindle checkpoint by allowing cells with abnormal chromosomal separation to enter anaphase. Thus, the design of new drugs that specifically target aurora-A rather than other checkpoint proteins might alleviate the resistance to Taxol-like clinical therapeutics observed in some tumors.

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