PEGylation of liposome decreases the susceptibility of liposomal drug in cancer photodynamic therapy

Biol Pharm Bull. 2004 Mar;27(3):443-4. doi: 10.1248/bpb.27.443.

Abstract

For the purpose of the avoidance of reticuloendothelial system (RES)-trapping, liposome entrapped benzoporphyrin derivative monoacid ring A (BPD-MA), which is used for cancer photodynamic therapy (PDT), was modified with polyethylene glycol (PEG-LipBPD-MA). Tumor accumulation of BPD-MA at 3 h after injection with PEG-LipBPD-MA in Meth A-sarcoma-bearing mice was significantly higher than that after injection with non-modified liposomal BPD-MA (Cont-LipBPD-MA) as expected. On the contrary, significant tumor growth suppression after PDT was observed only for Cont-LipBPD-MA but not for PEG-LipBPD-MA. Thus, PEGylation enhances the passive targeting of liposomal BPD-MA in tumor, but decreases the susceptibility of the drug in PDT.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Liposomes
  • Mice
  • Mice, Inbred BALB C
  • Photochemotherapy / methods*
  • Photosensitizing Agents / administration & dosage*
  • Photosensitizing Agents / therapeutic use*
  • Polyethylene Glycols / chemistry*
  • Porphyrins / administration & dosage*
  • Porphyrins / therapeutic use*
  • Sarcoma, Experimental / drug therapy
  • Technology, Pharmaceutical / methods

Substances

  • Liposomes
  • Photosensitizing Agents
  • Porphyrins
  • benzoporphyrin D
  • Polyethylene Glycols