MTHFR C677T mutation, factor II G20210A mutation and factor V Leiden as risks factor for youth retinal vein occlusion

Clin Ter. 2003 Sep-Oct;154(5):299-303.

Abstract

Objective: To determine whether methylene tetrahydrofolate reductase (MTHFR) C677T mutation, factor II G20210A mutation and factor V Leiden are risk factors for retinal vein occlusion (RVO) in patients under fifty years of age.

Methods: Comparison of 29 patients, under 50 years old of age, as affected RVO and 62 age matched normal controls. Plasma MTHFR C677T genotype, Factor II G20210A genotype, Factor V Leiden genotype, S protein level, C protein level, APCR presence (Actived Protein C Resistance), homocysteine level and Beta-thromboglobulin level were determined.

Results: Seventeen RVO patients and twenty-one controls were heterozygous for the MTHFR C677T mutation. Three RVO patients and twenty-three controls were homozygous for the MTHFR C677T mutation. Three RVO patients and two controls were heterozygous for the factor II G20210A mutation. One control was heterozygous for the factor V Leiden.

Conclusions: This study fails to demonstrate that these mutations are risk factors for RVO in patients under fifty years of age.

Publication types

  • Comparative Study

MeSH terms

  • Activated Protein C Resistance
  • Adolescent
  • Adult
  • Age Factors
  • Alleles
  • Analysis of Variance
  • Data Interpretation, Statistical
  • Factor V / genetics*
  • Female
  • Genotype
  • Heterozygote
  • Homocysteine / blood
  • Homozygote
  • Humans
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Middle Aged
  • Mutation*
  • Point Mutation
  • Prothrombin / genetics*
  • Retinal Vein Occlusion / etiology
  • Retinal Vein Occlusion / genetics*
  • Risk Factors
  • Sex Factors

Substances

  • factor V Leiden
  • Homocysteine
  • Factor V
  • Prothrombin
  • Methylenetetrahydrofolate Reductase (NADPH2)