Clinical and echocardiographic assessment of pregnant women with valvular heart diseases--maternal and fetal outcome

Int J Cardiol. 2004 Mar;94(1):15-23. doi: 10.1016/j.ijcard.2003.03.017.


The study aimed to compare the outcome of pregnancy in women with valvular heart diseases.

Material: Two hundred and fifty-nine pregnant women with cardiac diseases, aged 18-42, were observed. Group I-158 patients with mitral valve disease: 30 patients with mitral stenosis; 44 patients with mitral regurgitation, 33 patients with combined mitral valve disease, 51 patients with mitral valve prolapse; Group II-54 patients with aortic valve disease: 32 patients with aortic stenosis, 22 with aortic regurgitation; Group III-47 patients after valve replacement (36 mechanical; 11 homograft valves). Medical history and physical examination, NYHA class assessment, ECG, and echocardiography were performed during consecutive trimesters of pregnancy and after delivery.

Results: Clinical deterioration was observed in 38 patients-in 25 women of Group I, 6 women of Group II, and 7 women of Group III. Newborns outcome : 250 healthy (10 prematures, 12 with intrauterine growth retardation), 6 aborted, 2 stillbirths, 1 neonatal death. Method of delivery : 200 vaginally, 53 cesarean sections.

Conclusions: (1). Pregnants with critical mitral valve stenosis form a high-risk group of life-threatening complications. (2) In women with severe aortic stenosis, pregnancy could lead to sudden clinical status deterioration. (3) Cardiac complications can be expected in patients with left ventricular enlargement and its depressed function. (4) Key factors influencing successful course of pregnancy and labour in patients with prosthetic valves: adequate left ventricular function, properly functioning valves, and effective anticoagulation.

MeSH terms

  • Adolescent
  • Adult
  • Aortic Valve
  • Aortic Valve Insufficiency / diagnosis
  • Aortic Valve Insufficiency / surgery
  • Aortic Valve Stenosis / diagnosis
  • Aortic Valve Stenosis / surgery
  • Echocardiography*
  • Female
  • Heart Valve Diseases / diagnosis*
  • Heart Valve Diseases / diagnostic imaging
  • Heart Valve Diseases / surgery
  • Heart Valve Prosthesis Implantation
  • Humans
  • Infant, Newborn
  • Mitral Valve
  • Mitral Valve Insufficiency / diagnosis
  • Mitral Valve Insufficiency / surgery
  • Mitral Valve Stenosis / diagnosis
  • Mitral Valve Stenosis / surgery
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / diagnosis*
  • Pregnancy Complications, Cardiovascular / diagnostic imaging
  • Pregnancy Outcome
  • Treatment Outcome