Role of xanthine oxidase in conduit artery endothelial dysfunction in cigarette smokers

Am J Cardiol. 2004 Mar 1;93(5):664-8. doi: 10.1016/j.amjcard.2003.11.046.

Abstract

Xanthine oxidase contributes to oxidant stress and has been proposed as a risk factor for endothelial dysfunction. We studied the role of xanthine oxidase in conduit artery endothelial dysfunction in 12 smokers and 12 controls. Conduit artery vasodilation was impaired in smokers (4.3%) compared with controls (7.9%) (p = 0.006) and improved with xanthine oxidase inhibition in smokers (9.2%, p <0.001).

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Allopurinol / pharmacology
  • Blood Flow Velocity / drug effects
  • Blood Flow Velocity / physiology
  • Brachial Artery / diagnostic imaging
  • Brachial Artery / drug effects
  • Brachial Artery / physiopathology*
  • Cross-Over Studies
  • Endothelium, Vascular / diagnostic imaging
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiopathology*
  • Enzyme Inhibitors / pharmacology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Single-Blind Method
  • Smoking / physiopathology*
  • Ultrasonography
  • Vasodilation / drug effects
  • Vasodilation / physiology
  • Xanthine Oxidase / antagonists & inhibitors
  • Xanthine Oxidase / physiology*

Substances

  • Enzyme Inhibitors
  • Allopurinol
  • Xanthine Oxidase