Disappearance of Crohn's ulcers in the terminal ileum after thalidomide therapy

Can J Gastroenterol. 2004 Feb;18(2):101-4. doi: 10.1155/2004/296736.

Abstract

A case of intractable Crohn's disease unresponsive to all forms of therapy, including multiple operations and medication, is reported. The patient responded to thalidomide and this has resulted in the disappearance of the disease in the neoterminal ileum. Thalidomide may be a valuable treatment in intractable cases of Crohn's disease. The case is presented in a chronological fashion and endoscopic photographs documenting the disappearance of the disease are presented.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Colonoscopy
  • Contraindications
  • Crohn Disease / drug therapy*
  • Crohn Disease / pathology
  • Humans
  • Ileal Diseases / drug therapy*
  • Ileal Diseases / pathology
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Practice Guidelines as Topic
  • Thalidomide / therapeutic use*
  • Time Factors
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

  • Immunosuppressive Agents
  • Tumor Necrosis Factor-alpha
  • Thalidomide