Successful treatment of a critically ill patient with disseminated coccidioidomycosis, using adjunctive interferon-gamma

Clin Infect Dis. 2004 Mar 15;38(6):910-2. doi: 10.1086/382075. Epub 2004 Feb 26.


Conventional antifungal therapy was not successful for a critically ill patient who had been hospitalized for 137 days in the intensive care unit with disseminated Coccidioides immitis infection and respiratory failure. The addition of interferon- gamma to the therapeutic regimen resulted in improvement and discharge from the hospital. Adjunctive interferon- gamma used in the successful treatment of severe coccidioidomycosis has not been reported previously.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use
  • Coccidioidomycosis / drug therapy*
  • Critical Care
  • Critical Illness*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Intensive Care Units
  • Interferon-gamma / therapeutic use*
  • Middle Aged


  • Antifungal Agents
  • Interferon-gamma