Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats

Acta Pharmacol Sin. 2004 Mar;25(3):293-6.


Aim: To investigate the mechanism of brain interleukin-1 beta (IL-1 beta) in reserpine-induced behavioral depression in rats.

Methods: Porsult swim test was used in the measurement of depressive behavior and ELISA was used in measurement of brain IL-1 beta.

Results: Intraperitoneal injection of reserpine (0, 4, 6, and 8 mg/kg, ip) increased floating time in the Porsult swim test in a dose-and time-dependent manner in rats. Intracerebroventricular injection (icv) of IL-1 beta receptor antagonist (IL-1ra, 6 mg/kg) blocked the increment of floating time in Porsult swim test at 48 and 72 h after reserpine injection, but not at 1 and 24 h after injection. Brain IL-1 beta increased after reserpine treatment in posterior cortex, hippocampus, and hypothalamus. The increase of IL-1 beta concentration starts at 24 hours after injection of reserpine and reached the peak at 48 h.

Conclusion: Reserpine induced behavioral depression partially via brain interleukin-1 beta generation.

MeSH terms

  • Animals
  • Brain / metabolism*
  • Cerebral Cortex / metabolism
  • Depression / chemically induced
  • Depression / metabolism*
  • Hippocampus / metabolism
  • Hypothalamus / metabolism
  • Injections, Intraventricular
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / metabolism*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Interleukin-1 / antagonists & inhibitors
  • Reserpine
  • Sialoglycoproteins / pharmacology*


  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Receptors, Interleukin-1
  • Sialoglycoproteins
  • Reserpine