Regulation of mRNA translation by protein folding in the endoplasmic reticulum

Trends Biochem Sci. 2004 Mar;29(3):152-8. doi: 10.1016/j.tibs.2004.01.004.


The process of protein secretion is intimately linked to the rate and potential of proper folding and assembly of secretory proteins. The efficiency of protein folding is communicated to the cytoplasm via several signal transduction pathways. This regulates the rate of polypeptide chain synthesis and induction of genes encoding functions that reduce protein-folding load on the endoplasmic reticulum (ER). This review summarizes recent insights into the mechanisms that couple protein translation with protein folding in the ER.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Codon
  • Endoplasmic Reticulum / genetics
  • Endoplasmic Reticulum / metabolism*
  • Eukaryotic Initiation Factor-2 / metabolism
  • Gene Expression Regulation
  • Models, Biological
  • Phosphorylation
  • Protein Biosynthesis*
  • Protein Folding*
  • Protein Kinases / metabolism
  • RNA, Messenger / metabolism*
  • Ribosomes / metabolism
  • Signal Transduction


  • Codon
  • Eukaryotic Initiation Factor-2
  • RNA, Messenger
  • Protein Kinases