Abstract
Hepatitis C virus isolates which disclosed a novel genotype 1-associated restriction pattern by restriction fragment length polymorphism analysis were characterized. Except for a mother and child pair, the patients were unrelated. Sequence analysis showed a G-->A substitution leading to a new RsaI recognition site. Phylogenetic analysis revealed that these isolates constitute a novel genetic lineage within the main cluster of genotype 1 strains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5' Untranslated Regions / chemistry
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5' Untranslated Regions / genetics*
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Argentina
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Base Sequence
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Geography
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Hepacivirus / classification
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Hepacivirus / genetics
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Hepacivirus / isolation & purification*
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Hepatitis C / virology
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Humans
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Molecular Sequence Data
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Phenotype
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Polymorphism, Restriction Fragment Length
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Restriction Mapping
Associated data
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GENBANK/AY376832
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GENBANK/AY376833
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GENBANK/AY376834
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GENBANK/AY376835
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GENBANK/AY376836
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GENBANK/AY376837