Hepatitis C virus isolates from Argentina disclose a novel genotype 1-associated restriction pattern

J Clin Microbiol. 2004 Mar;42(3):1298-301. doi: 10.1128/JCM.42.3.1298-1301.2004.

Abstract

Hepatitis C virus isolates which disclosed a novel genotype 1-associated restriction pattern by restriction fragment length polymorphism analysis were characterized. Except for a mother and child pair, the patients were unrelated. Sequence analysis showed a G-->A substitution leading to a new RsaI recognition site. Phylogenetic analysis revealed that these isolates constitute a novel genetic lineage within the main cluster of genotype 1 strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5' Untranslated Regions / chemistry
  • 5' Untranslated Regions / genetics*
  • Argentina
  • Base Sequence
  • Geography
  • Hepacivirus / classification
  • Hepacivirus / genetics
  • Hepacivirus / isolation & purification*
  • Hepatitis C / virology
  • Humans
  • Molecular Sequence Data
  • Phenotype
  • Polymorphism, Restriction Fragment Length
  • Restriction Mapping

Substances

  • 5' Untranslated Regions

Associated data

  • GENBANK/AY376832
  • GENBANK/AY376833
  • GENBANK/AY376834
  • GENBANK/AY376835
  • GENBANK/AY376836
  • GENBANK/AY376837