[The protective effect of magnesium-aspartate-procaine cardioplegia on the hypertrophied left ventricle of the mini-pig (author's transl)]

Thoraxchir Vask Chir. 1978 Jun;26(3):205-8. doi: 10.1055/s-0028-1096624.
[Article in German]


After induction of left ventricular hypertrophy by supravalvar constriction of the ascending aorta in mini pigs (ATP and lactate) were measured under different cardioplegic conditions. In normothermia and plain anoxic arrest ATP decrease and lactate increase were significantly slower in hypertrophied myocardium compared to normal myocardium. Injection cardioplegia using magnesium-aspartate-procaine at 37 degrees C did not influence the ATP decrease and lactate increase in the hypertrophied ventricle, whereas in the normal heart it showed some protection according to these parameters. Optimal ATP preservation and the lowest lactate increase rate were achieved in left ventricular hypertrophy by combined application of magnesium-aspartate-procaine and hypothermia of 25 degrees C. We conclude that normothermic injection cardioplegia has no protective effect on the hypertrophied left ventricle, whereas additional hypothermia can improve magnesium-aspartate-procaine cardioplegia significantly.

Publication types

  • English Abstract

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Aspartic Acid / pharmacology*
  • Cardiomegaly / metabolism*
  • Heart / drug effects*
  • Heart Arrest, Induced*
  • Heart Ventricles
  • Lactates / metabolism
  • Magnesium / pharmacology*
  • Myocardium / metabolism
  • Procaine / pharmacology*
  • Swine


  • Lactates
  • Aspartic Acid
  • Procaine
  • Adenosine Triphosphate
  • Magnesium