Protein C in patients with alcoholic cirrhosis and other liver diseases

J Hepatol. 1992 Mar;14(2-3):163-7. doi: 10.1016/0168-8278(92)90153-g.

Abstract

The coagulation inhibitor protein C was measured in 151 patients with various liver diseases. The protein C level was significantly decreased in patients with alcoholic cirrhosis (n = 73) compared to patients with steatosis (n = 24) (40 +/- 2%) vs. 88 +/- 4%, mean S.E., p less than 0.001). It was also decreased in cases of acute liver damage (n = 8) and in patients with non-alcoholic cirrhosis (n = 15) (35 +/- 7% and 36 +/- 4%, respectively). A significant correlation was found between protein C and Normotest, antithrombin, heparin cofactor II, (r = 0.83, r = 0.82, r = 0.81, respectively, p less than 0.001). There was also a significant correlation between protein C and serum concentrations of albumin (r = 0.61, p less than 0.001), but a negative association to bilirubin (r = -0.56). No significant association was found between protein C and aspartate aminotransferase, alaline aminotransferase, and gamma-glutamyltranspeptidase. In conclusion, protein C is low in advanced liver diseases and gives the same amount and type of information as Normotest, antithrombin and heparin cofactor II.

Publication types

  • Comparative Study

MeSH terms

  • Acute Disease
  • Biopsy
  • Chronic Disease
  • Female
  • Humans
  • Liver / pathology
  • Liver Cirrhosis / blood
  • Liver Cirrhosis, Alcoholic / blood*
  • Liver Diseases / blood*
  • Liver Function Tests
  • Male
  • Prospective Studies
  • Protein C / metabolism*
  • Serum Albumin / analysis

Substances

  • Protein C
  • Serum Albumin