Sarcoidosis, race, and short-term outcomes following lung transplantation

Chest. 2004 Mar;125(3):990-6. doi: 10.1378/chest.125.3.990.


Background: Patients with sarcoidosis, many of whom are African American, may require lung transplantation (LT). Little is known about survival following LT for sarcoidosis.

Objective: To determine short-term mortality following LT for sarcoidosis, to evaluate if survival after LT for sarcoidosis is similar to outcomes after LT for other diseases, and to investigate the impact of race on the results of LT.

Design: Retrospective review.

Patients: All patients who underwent LT, irrespective of diagnosis, in the United States between January 1995 and December 2000.

Measurements: Vital status at 30 days after LT and cause of death.

Results: During the study period, 4,721 LTs were performed; of these 133 LTs (2.8%) were for sarcoidosis. Approximately 83% of patients with sarcoidosis survived following LT compared to 91% of persons undergoing transplantation for other reasons (p = 0.002). In multivariate analysis controlling both for health insurance status and other factors known to affect survival after LT, patients with sarcoidosis were no more likely to die than persons undergoing transplantation for other conditions (adjusted odds ratio for death, 1.45; 95% confidence interval [CI], 0.84 to 2.48). Significant predictors of mortality included the following: undergoing combined heart-lung transplant, need for mechanical ventilation, treatment in an ICU at time of LT, pre-LT FEV(1), need for supplemental oxygen, and donor age. Both recipient race and donor race significantly affected short-term survival. African-American patients were nearly 50% more likely to die (adjusted odds ratio, 1.49; 95% CI, 1.01 to 2.20). This difference based on race persisted after excluding heart-lung recipients and after controlling for recipient-donor racial mismatch. The most frequent cause of death for patients with sarcoidosis was graft failure, while infection was the primary cause of death among other LT patients.

Conclusions: Patients with sarcoidosis do as well as patients undergoing LT for other diseases. Race is an important factor affecting survival after LT.

MeSH terms

  • Black or African American*
  • Cause of Death
  • Female
  • Humans
  • Lung Transplantation / ethnology*
  • Lung Transplantation / mortality
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Retrospective Studies
  • Sarcoidosis, Pulmonary / ethnology*
  • Sarcoidosis, Pulmonary / mortality
  • Sarcoidosis, Pulmonary / physiopathology
  • Sarcoidosis, Pulmonary / surgery
  • Survival Rate
  • Tissue Donors
  • Treatment Outcome