Association of APOE polymorphisms with disease severity in MS is limited to women

Neurology. 2004 Mar 9;62(5):811-4. doi: 10.1212/01.wnl.0000113721.83287.83.


The authors studied the association of an exon 4 (E4*epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Apolipoprotein E4
  • Apolipoproteins E / genetics*
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / physiopathology
  • Polymorphism, Genetic
  • Promoter Regions, Genetic
  • Severity of Illness Index
  • Sex Factors


  • Apolipoprotein E4
  • Apolipoproteins E