Pulmonary emphysema in a nonsmoker with normal alpha-1-antitrypsin

J Ky Med Assoc. 1992 Jul;90(7):327-30.


Premature and rapidly progressing emphysema of the lung is unique in the absence of cigarette smoking or an inherited homozygous alpha-1-antitrypsin deficiency. We describe a young man with radiographic evidence of early onset bullous emphysema without the usual risk factors and provide a review of the alternative explanations proposed for this form of lung damage.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Humans
  • Male
  • Pulmonary Emphysema / diagnostic imaging
  • Pulmonary Emphysema / etiology*
  • Radiography
  • Risk Factors
  • Smoking / adverse effects*
  • alpha 1-Antitrypsin Deficiency*