Somatostatin is a specific inhibitor of SDF-1alpha-induced T cell infiltration

Clin Exp Immunol. 2004 Mar;135(3):434-9. doi: 10.1111/j.1365-2249.2003.02370.x.


The chemokine stromal cell-derived factor 1alpha (SDF-1alpha) is a potent stimulator of T cell infiltration into three-dimensional type I collagen matrices as demonstrated using T cells freshly isolated from blood and an activated T cell clone. The neuropeptide somatostatin selectively inhibits SDF-1alpha induced T cell infiltration by the same T cells including CD4 as well as CD8 positive cells, while somatostatin does not inhibit 'spontaneous' T cell infiltration. A number of other neuropeptides and opioids do not inhibit SDF-1alpha-induced T cell infiltration, indicating that the inhibitory effect is somatostatin-specific. The neuropeptide antagonist cyclosomatostatin abrogated the inhibitory effect of somatostatin on T cell infiltration, indicating that the effect of somatostatin is mediated via specific somatostatin receptors. Somatostatin does not inhibit SDF-1alpha-induced T cell attachment to the collagen substrate, which indicates that this neuropeptide specifically inhibits the process of chemokine-induced T cell penetration and migration through the collagen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Chemokine CXCL12
  • Chemokines / immunology
  • Chemokines, CXC / antagonists & inhibitors*
  • Chemotaxis, Leukocyte / drug effects
  • Flow Cytometry
  • Humans
  • Integrin beta1 / metabolism
  • Lymphocyte Activation / immunology
  • Neuropeptides / pharmacology
  • Receptors, Chemokine / metabolism
  • Somatostatin / pharmacology*
  • T-Lymphocyte Subsets / drug effects*
  • T-Lymphocyte Subsets / immunology


  • CXCL12 protein, human
  • Chemokine CXCL12
  • Chemokines
  • Chemokines, CXC
  • Integrin beta1
  • Neuropeptides
  • Receptors, Chemokine
  • Somatostatin