The Bacterial Sm-like Protein Hfq: A Key Player in RNA Transactions

Mol Microbiol. 2004 Mar;51(6):1525-33. doi: 10.1111/j.1365-2958.2003.03935.x.

Abstract

The conserved RNA-binding protein Hfq, originally discovered in Escherichia coli as a host factor for Qbeta replicase, has emerged as a pleiotropic regulator that modulates the stability or the translation of an increasing number of mRNAs. During the past 5 years, Hfq-mediated control has been an area of increasing focus because the protein has been linked to the action of many versatile RNA-based regulators that use basepairing interactions to regulate the expression of target mRNAs. The recent findings that Hfq assists in bimolecular RNA-RNA interactions and is similar structurally and functionally to eukaryotic Sm proteins have further fueled interest in this important post-transcriptional regulator. Here, we summarize the history of Hfq and highlight results that have led to an important gain in insight into the physiology, biochemistry and evolution of Hfq and its homologues.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Conserved Sequence
  • Crystallography, X-Ray
  • Escherichia coli Proteins / metabolism*
  • Host Factor 1 Protein* / chemistry
  • Host Factor 1 Protein* / metabolism
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Bacterial / chemistry
  • RNA, Bacterial / genetics*
  • RNA, Bacterial / metabolism
  • RNA, Messenger / chemistry
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / metabolism

Substances

  • Escherichia coli Proteins
  • Host Factor 1 Protein
  • RNA, Bacterial
  • RNA, Messenger
  • RNA-Binding Proteins