Prophylactic factor replacement in hemophilia

Blood Rev. 2004 Jun;18(2):101-13. doi: 10.1016/S0268-960X(03)00038-9.


Prophylaxis, the regular infusion of coagulation factor concentrates to severe hemophiliacs, has been an evolving therapeutic tool of management for the past three decades. Multiple clinical trials have and continue to be conducted in the field of prophylaxis in an attempt to determine ideal regimens of prophylaxis, its benefits, its risks and costs, and to address still unanswered questions; who to place on prophylaxis, when to start prophylaxis, when (if ever) to stop prophylaxis, etc. We present a detailed review and discussion of the evolution of prophylaxis as a tool in managing patients with hemophilia and we address the major issues and still unanswered questions.

Publication types

  • Review

MeSH terms

  • Cost of Illness
  • Factor IX / therapeutic use*
  • Factor VIII / therapeutic use*
  • Hemophilia A / complications
  • Hemophilia A / drug therapy*
  • Hemophilia A / economics
  • Hemophilia A / prevention & control*
  • Hemophilia B / complications
  • Hemophilia B / drug therapy*
  • Hemophilia B / economics
  • Hemophilia B / prevention & control*
  • Humans
  • Infant
  • Infant, Newborn
  • Joint Diseases / etiology
  • Joint Diseases / prevention & control


  • F8 protein, human
  • Factor VIII
  • Factor IX