Penicillin Derived C2-symmetric Dimers as Novel Inhibitors of HIV-1 Proteinase

J Med Chem. 1992 Aug 7;35(16):3080-1. doi: 10.1021/jm00094a024.

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cell Line
  • Cytopathogenic Effect, Viral / drug effects
  • Dioxoles / pharmacology*
  • Dioxoles / therapeutic use
  • HIV Protease Inhibitors*
  • HIV-1 / drug effects*
  • HIV-1 / enzymology
  • HIV-1 / physiology
  • Humans
  • Penicillins / pharmacology*
  • Virus Replication / drug effects
  • X-Ray Diffraction

Substances

  • Antiviral Agents
  • Dioxoles
  • HIV Protease Inhibitors
  • Penicillins
  • disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate