Epidermal growth factor receptor: elements of intracellular communication

J Membr Biol. 1992 Jun;128(2):81-9. doi: 10.1007/BF00231881.


While EGF has an important function in cell growth regulation, the molecular mechanisms by which intracellular signal connect the EGF: receptor complex on the plasma membrane with the initiation of DNA synthesis and mitogenesis is not well understood. The discovery that rasGAP, PI-3 kinase and PLC-gamma 1 are substrates for the EGF receptor tyrosine kinase has provided a beginning in understanding the biochemistry underlying growth factor receptor transduction.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ErbB Receptors / metabolism*
  • Phosphorylation
  • Signal Transduction*
  • Tyrosine / metabolism


  • Tyrosine
  • ErbB Receptors