Use of cidofovir in polyomavirus BK viral nephropathy in two renal allograft recipients

Nephrology (Carlton). 2003 Dec;8(6):318-23. doi: 10.1111/j.1440-1797.2008.00214.x.


Polyomavirus BK viral allograft nephropathy is a potentially reversible cause of deteriorating function of kidney allografts. Initial treatment involves reducing immunosuppressive medications, with low-dose cidofovir an effective alternative in refractory cases. We describe two cases of BK viral allograft nephropathy responding to low-dose cidofovir after a reduction in immunosuppressive medications failed to clear the virus or stabilize the deterioration in renal function. There were no significant side-effects from this treatment in either patient.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use*
  • BK Virus*
  • Cidofovir
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use*
  • Female
  • Humans
  • Kidney Diseases / surgery
  • Kidney Diseases / virology*
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Organophosphonates*
  • Organophosphorus Compounds / therapeutic use*
  • Polyomavirus Infections / drug therapy*
  • Transplantation, Homologous
  • Tumor Virus Infections / drug therapy*


  • Antiviral Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Cytosine
  • Cidofovir