Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis

J Am Coll Cardiol. 2004 Feb 4;43(3):317-27. doi: 10.1016/j.jacc.2003.07.046.


Recent cross-sectional, population-based echocardiographic studies show that about half of all patients with heart failure have preserved left ventricular systolic function (HF-PSF). Cohort studies of hospitalized patients show a smaller proportion of HF-PSF. Compared to those with reduced systolic function, patients with HF-PSF are more often female, older, less likely to have coronary artery disease, and more likely to have hypertension. Patients with HF-PSF are less symptomatic and receive different pharmacologic therapy than patients with reduced systolic function. Morbidity and mortality rates in patients with HF-PSF are high but not quite as high as in patients with reduced systolic function. Though much has recently been learned about the syndrome of HF-PSF, many questions remain to be answered, not least how it should be treated.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiovascular Agents / therapeutic use
  • Comorbidity
  • Female
  • Heart Failure / drug therapy
  • Heart Failure / economics
  • Heart Failure / epidemiology*
  • Heart Failure / physiopathology*
  • Hospitalization / economics
  • Humans
  • Hypertension / epidemiology*
  • Male
  • Middle Aged
  • Myocardial Ischemia / epidemiology*
  • Prognosis
  • Quality of Life
  • Ventricular Function, Left / physiology*


  • Cardiovascular Agents