Contemporary results of mitral valve repair for infective endocarditis

J Am Coll Cardiol. 2004 Feb 4;43(3):386-92. doi: 10.1016/j.jacc.2003.09.034.


Objectives: We sought to evaluate the feasibility and immediate and late results of mitral valve repair (MVRep) for acute and healed endocarditis.

Background: Improvements in techniques of MVRep have extended its feasibility in complex lesions, but experience with endocarditis is limited.

Methods: Among 78 patients operated on for mitral endocarditis between 1990 and 1999, 63 underwent MVRep. The repair was performed for acute endocarditis in 25 patients (40%) at a median of 20 days after the onset of treatment and in 38 patients (60%) for healed endocarditis after a median of 11 months.

Results: Repair of the mitral valve was feasible in 63 patients (81%). This repair involved annuloplasty in 61 patients (97%), valve resection in 49 (78%), shortening or transposition of chordae in 29 (46%), suture of perforation in 18 (29%), a pericardial patch in 12 (19%), and a partial mitral homograft in 7 (11%). Associated procedures were aortic valve replacement in 11 patients, bypass grafting in 3, and tricuspid repair in 2. Early complications were two deaths (3.2%), one re-operation for severe mitral regurgitation and one re-operation for subsequent aortic endocarditis. The seven-year rate of event-free survival was 78 +/- 6% in the global series. Multivariate predictors of event-free survival were hypertension (p < 0.006) and intervention for acute endocarditis (p < 0.026). Five-year survival rates were 96 +/- 4% after MVRep for acute endocarditis and 91 +/- 5% for healed endocarditis.

Conclusions: Mitral valve repair is frequently feasible and gives good results in patients with infective endocarditis. Patients operated on for acute endocarditis experience more events during follow-up than those operated on after healed endocarditis but have excellent late survival.

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Cardiac Surgical Procedures / methods*
  • Endocarditis, Bacterial / microbiology
  • Endocarditis, Bacterial / surgery*
  • Feasibility Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mitral Valve / surgery*
  • Staphylococcal Infections / complications
  • Streptococcal Infections / complications
  • Treatment Outcome
  • Wound Healing