Abstract
Mannosyltransferases play a crucial role in mycobacterial cell-wall biosynthesis and are potential new drug targets for the treatment of tuberculosis. Herein, we describe the synthesis of alpha-(1-->2)- and alpha-(1-->6)-linked mannopyranosyl disaccharides possessing a 5-azidonaphthlene-1-sulfonamidoethyl group as photoaffinity probes for active-site labeling studies of mannosyltransferases in Mycobacterium tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Disaccharides / chemical synthesis*
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Disaccharides / chemistry
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Disaccharides / metabolism
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Mannose / chemical synthesis*
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Mannose / chemistry
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Mannose / metabolism
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Mannosyltransferases / analysis*
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Mannosyltransferases / chemistry
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Mannosyltransferases / metabolism
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Molecular Structure
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Mycobacterium tuberculosis / enzymology
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Photoaffinity Labels / analysis*
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Photoaffinity Labels / chemical synthesis*
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Photoaffinity Labels / chemistry
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Photoaffinity Labels / metabolism
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Structure-Activity Relationship
Substances
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Disaccharides
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Photoaffinity Labels
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Mannosyltransferases
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Mannose