Voxel-based morphometry of human brain with age and cerebrovascular risk factors

Neurobiol Aging. 2004 Apr;25(4):455-63. doi: 10.1016/j.neurobiolaging.2003.09.002.


The objectives of this study were to evaluate the correlations of the volumes of the gray matter and white matter with age, and the correlations of the tissue probabilities of the gray matter and white matter with age and several cerebrovascular risk factors. We obtained magnetic resonance (MR) images of the brain and clinical information from 769 normal Japanese subjects. We processed the MR images automatically by correcting for inter-individual differences in brain size and shape, and by segmenting the MR images into the gray matter and white matter. Volumetry of the brain revealed a significant negative correlation between the gray matter volume and age, which was not observed between white matter volume and age. Voxel-based morphometry showed that age, systolic blood pressure, and alcohol drinking correlated with the regional tissue probabilities of the gray matter and white matter.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging / metabolism
  • Aging / pathology*
  • Alcohol Drinking / metabolism
  • Blood Pressure / physiology
  • Brain / metabolism
  • Brain / pathology*
  • Cerebrovascular Disorders / metabolism
  • Cerebrovascular Disorders / pathology*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy / methods
  • Male
  • Middle Aged
  • Risk Factors
  • Statistics, Nonparametric