Differential expression of the nm23 genes in the developing human trophoblast

Placenta. 2004 Jan;25(1):20-8. doi: 10.1016/j.placenta.2003.08.003.


NDP kinases are the non-specific enzymes which catalyse the synthesis of the NTPs through a transfer reaction using ATP as phosphoryl donor. In addition to their enzymatic activity, they display other not yet explained functions related to cell growth, differentiation and apoptosis, embryonic development, tumour progression and metastasis. In this study, the expression patterns of the three highly related NDP kinases A, B and C isoforms were investigated in the developing human trophoblast. Both NDP kinase A and B were found to be primarily present in the villous and extravillous cytotrophoblasts, while NDP kinase C was found almost exclusively in the syncytiotrophoblast layer. This suggests that NDP kinase A and B could be a marker for the mononuclear stage of differentiation of villous trophoblasts, while NDP kinase C could be a marker of the syncytiotrophoblast layer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Embryonic and Fetal Development / physiology
  • Eye Proteins / metabolism
  • Female
  • Gene Expression Regulation, Developmental / genetics*
  • Gestational Age
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Ki-67 Antigen / analysis
  • NM23 Nucleoside Diphosphate Kinases
  • Nerve Tissue Proteins / metabolism
  • Nucleoside-Diphosphate Kinase / genetics*
  • Nucleoside-Diphosphate Kinase / metabolism
  • Pregnancy
  • Trophoblasts / enzymology*


  • Eye Proteins
  • Ki-67 Antigen
  • NDP protein, human
  • NM23 Nucleoside Diphosphate Kinases
  • Nerve Tissue Proteins
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase