Influenza A virus-associated acute necrotizing encephalopathy in the United States

Pediatr Infect Dis J. 2004 Mar;23(3):259-63. doi: 10.1097/01.inf.0000115631.99896.41.


During the past several years, influenza-associated acute necrotizing encephalopathy has been well-recognized in Asia but has not yet been reported in the United States. We describe a 28-month-old patient who displayed the classical clinical features of acute necrotizing encephalopathy in association with a documented influenza A infection. This disease is characterized by fever, a rapid alteration in consciousness and seizures, with radiologic involvement of the bilateral thalami and cerebellum.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anti-Bacterial Agents / therapeutic use
  • Brain Diseases / diagnosis
  • Brain Diseases / drug therapy
  • Brain Diseases / epidemiology
  • Brain Diseases / virology*
  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Humans
  • Influenza A virus*
  • Influenza, Human / complications*
  • Influenza, Human / epidemiology
  • United States / epidemiology


  • Anti-Bacterial Agents