A possible association between fluoxetine use and suicide

J Anal Toxicol. 1992 Mar-Apr;16(2):142-5. doi: 10.1093/jat/16.2.142.


Fluoxetine has been available for use as an antidepressant since early 1988. Numerous reports have indicated that it is at least as good as some of the tricyclic antidepressants and that it does not produce as serious toxicity as the tricyclics. Recently, however, case reports have suggested that it may produce suicidal tendencies in some patients. The present report provides data from a medical examiner's office regarding the number of cases in which fluoxetine has been detected and the proportion certified as suicides.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antidepressive Agents, Tricyclic / adverse effects
  • Female
  • Fluoxetine / adverse effects*
  • Fluoxetine / analysis
  • Humans
  • Male
  • Middle Aged
  • Suicide*


  • Antidepressive Agents, Tricyclic
  • Fluoxetine