Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women

Metabolism. 2004 Mar;53(3):280-3. doi: 10.1016/j.metabol.2003.10.004.


Plasma adiponectin concentrations were measured before and after moderate weight loss in 20 obese women, divided at baseline into insulin-resistant (IR) and insulin-sensitive (IS) subgroups on the basis of their steady-state plasma glucose (SSPG) concentration at the end of a 180-minute infusion of octreotide, glucose, and insulin. The groups were similar in age and body weight and lost comparable amounts of weight (8 to 9 kg) during the weight loss period. Fasting plasma insulin and SSPG concentrations were significantly higher (P <.001) and adiponectin concentrations somewhat lower (P =.10) in the IR group (P <.001) at baseline. Both SSPG and plasma insulin concentrations decreased in IR subjects (P <.001), but did not change in IS individuals. Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adiponectin
  • Adult
  • Blood Glucose / metabolism
  • Body Mass Index
  • Female
  • Humans
  • Insulin / blood
  • Insulin Resistance / physiology*
  • Intercellular Signaling Peptides and Proteins*
  • Middle Aged
  • Obesity / blood*
  • Proteins / metabolism*
  • Weight Loss / physiology*


  • Adiponectin
  • Blood Glucose
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Proteins