Role of Nitric Oxide in Tumor Angiogenesis

Cancer Treat Res. 2004;117:155-67. doi: 10.1007/978-1-4419-8871-3_11.

Abstract

Nitric oxide (NO) is an important signalling molecule that acts in many tissues to regulate different physiological and pathological processes. We have contributed to demonstrate that NO stimulates angiogenesis and mediates the effect of different angiogenic molecules. In human tumors NOS expression and activity correlate with tumor growth and aggressiveness, through angiogenesis stimulation and regulation of angiogenic factor expression. Drugs affecting the NOS pathway appear promising antitumor strategies by reducing edema, inhibiting angiogenesis and facilitating the delivery of chemotherapeutical agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Neoplasms / blood supply*
  • Brain Neoplasms / metabolism*
  • Humans
  • Neoplasms / pathology
  • Neovascularization, Pathologic*
  • Nitric Oxide*
  • Protein Isoforms

Substances

  • Protein Isoforms
  • Nitric Oxide