Computational simulation of chronic persistent virus infection: factors determining differences in clinical outcome of HHV-6, HIV-1 and HTLV-1 infections including aplastic, hyperplastic and neoplastic responses

Anticancer Res. 2004 Jan-Feb;24(1):187-97.


A computational model was recently designed to simulate cellular changes in the T cell immune system. The model was validated by simulating cell changes in viral infections which target the same CD4+ T cell, yet cause either hyperplastic, aplastic or neoplastic responses. Respective case material for comparison was available from human infections with human herpesvirus-6 (HHV-6), human immunodeficiency virus (HIV-1) or human T cell leukemia virus (HTLV-1). Starting with cell values for a healthy human individual, factorial changes that influence the individual course of the various infections were determined by an algorithm search procedure. Such factorial differences determining a clinical course with aplasia, hyperplasia or neoplasia are outlined and further discussed in this paper.

Publication types

  • Comparative Study

MeSH terms

  • Algorithms
  • Chronic Disease
  • Computer Simulation
  • HIV Infections / immunology*
  • HIV Infections / pathology
  • HIV-1*
  • HTLV-I Infections / immunology*
  • HTLV-I Infections / pathology
  • Herpesvirus 6, Human*
  • Human T-lymphotropic virus 1*
  • Humans
  • Hyperplasia
  • Models, Immunological*
  • Neoplasms / immunology
  • Neoplasms / virology*
  • Roseolovirus Infections / immunology*
  • Roseolovirus Infections / pathology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / virology