Nogo and axon regeneration

Curr Opin Neurobiol. 2004 Feb;14(1):118-24. doi: 10.1016/j.conb.2004.01.004.


Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo receptor subunit NgR, or blockers of the postreceptor components Rho-A and ROCK induce long-distance axonal regeneration and compensatory sprouting, accompanied by an impressive enhancement of functional recovery, in the rat and mouse spinal cord.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Axons / metabolism
  • Axons / physiology*
  • Humans
  • Myelin Proteins / genetics
  • Myelin Proteins / metabolism
  • Myelin Proteins / physiology*
  • Nerve Regeneration / physiology*
  • Nogo Proteins


  • Myelin Proteins
  • Nogo Proteins
  • RTN4 protein, human
  • Rtn4 protein, mouse
  • Rtn4 protein, rat