Multiple roles for ISWI in transcription, chromosome organization and DNA replication

Biochim Biophys Acta. 2004 Mar 15;1677(1-3):113-9. doi: 10.1016/j.bbaexp.2003.09.018.

Abstract

ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphatases / physiology*
  • Adenosine Triphosphate / metabolism
  • Animals
  • Chromatin Assembly and Disassembly
  • Chromosomes* / genetics
  • Chromosomes* / metabolism
  • Chromosomes* / ultrastructure
  • DNA Replication*
  • Gene Expression Regulation
  • Humans
  • Transcription Factors / physiology*
  • Transcription, Genetic*
  • Transcriptional Activation

Substances

  • ISWI protein
  • Transcription Factors
  • Adenosine Triphosphate
  • Adenosine Triphosphatases