Circulating endothelin-3 Levels in Patients With Sickle Cell Disease During Hydroxyurea Treatment

Haematologica. 2004 Mar;89(3):360-1.


Abnormal adhesion of red blood cells to the endothelium and the production of cytokines and vasoactive substances, such as endothelin-1 contribute to the pathogenesis of microvascular occlusion in sickle cell disease (SCD), even during the steady state. Endothelin-3 (ET-3) is a vasoconstrictive agent, which has not yet been studied in SCD.

Publication types

  • Letter

MeSH terms

  • Adult
  • Anemia, Sickle Cell / blood*
  • Anemia, Sickle Cell / drug therapy*
  • Antisickling Agents / therapeutic use*
  • Endothelin-3 / blood*
  • Female
  • Humans
  • Hydroxyurea / therapeutic use*
  • Male
  • Middle Aged


  • Antisickling Agents
  • Endothelin-3
  • Hydroxyurea