Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 23 (11), 2016-27

The Spindle Checkpoint, Aneuploidy, and Cancer


The Spindle Checkpoint, Aneuploidy, and Cancer

Rajnish Bharadwaj et al. Oncogene.


Cancer cells contain abnormal number of chromosomes (aneuploidy), which is a prevalent form of genetic instability in human cancers. Defects in a cell cycle surveillance mechanism called the spindle checkpoint contribute to chromosome instability and aneuploidy. In response to straying chromosomes in mitosis, the spindle checkpoint inhibits the ubiquitin ligase activity of the anaphase-promoting complex or cyclosome (APC/C), thus preventing precocious chromosome segregation and ensuring the accurate partition of the genetic material. We review recent progress toward the understanding of the molecular mechanism of the spindle checkpoint and its role in guarding genome integrity at the chromosome level.

Similar articles

See all similar articles

Cited by 168 PubMed Central articles

See all "Cited by" articles

Publication types


LinkOut - more resources