The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

Oncogene. 2004 Mar 15;23(11):2028-36. doi: 10.1038/sj.onc.1207389.


Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFbeta-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying beta-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting beta-TrCP as a means of anticancer therapy are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Ligases / metabolism*
  • Models, Biological
  • Neoplasms / genetics*
  • Substrate Specificity
  • Ubiquitins / metabolism*
  • beta-Transducin Repeat-Containing Proteins / genetics
  • beta-Transducin Repeat-Containing Proteins / metabolism*


  • Ubiquitins
  • beta-Transducin Repeat-Containing Proteins
  • Ligases