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. 2004 Feb;18(2):164-8.
doi: 10.1002/ptr.1178.

A Hot Water Extract of Chlorella Pyrenoidosa Reduces Body Weight and Serum Lipids in Ovariectomized Rats

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A Hot Water Extract of Chlorella Pyrenoidosa Reduces Body Weight and Serum Lipids in Ovariectomized Rats

Saburo Hidaka et al. Phytother Res. .

Abstract

The effects of a hot water extract of Chlorella pyrenoidosa, which contains chlorella growth factor (CGF), on the body weight, serum lipids, and the bone mass were evaluated using an ovariectomized rat as a model for postmenopausal bone loss. Rats were divided into four groups: sham-operated (Sham), Sham given the CGF solution, ovariectomized (OVX), and OVX given the CGF solution, respectively. Administration of the extract to OVX rats suppressed the body weight gain. After 7 weeks, the administration of the extract to the OVX group reduced increases in both serum total cholesterols and high-density lipoprotein (HDL) cholesterols. It also normalized the decrease of triglyceride level in the OVX group. The ovariectomy decreased the tibial bone mineral density (BMD) by 19%, and the administration of the extract to OVX rats did not inhibit this decrease. These results suggest that a dietary supplement of CGF may be useful to control the body weight and improve lipid metabolism of menopausal women.

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