Effect of dexamethasone and dipyrone on lingual and inferior alveolar nerve hypersensitivity following third molar extractions: preliminary report

J Orofac Pain. 2004 Winter;18(1):62-8.


Aims: To study the effect of dexamethazone and dipyrone on sensory changes in the innervation territories of the inferior alveolar, infraorbital, and lingual nerves caused by third molar extractions.

Methods: Fourteen patients (8 men and 6 women) were divided randomly into 2 groups. The first group received dipyrone preoperatively, while the second group received dipyrone and dexamethazone preoperatively. All patients in the study received a prophylactic preoperative dose of amoxicillin (500 mg) as well as dipyrone postoperatively. In all patients, a single mandibular third molar was removed, while in 2 patients the contralateral third molar was removed at a subsequent time. Electrical detection thresholds were assessed in the inferior alveolar, lingual, and infraorbital nerve regions prior to surgery and 2 and 8 days following surgery. The level of perioperative pain, difficulty of extraction, and distance of molar root apices from the inferior alveolar nerve canal were also assessed.

Results: Patients who received only dipyrone had significantly reduced lingual and inferior alveolar nerve electrical detection thresholds 2 days after surgery, which returned to nearly baseline values by the eighth day postoperatively. In patients who received dexamethasone, no significant reduction in the electrical detection threshold was found.

Conclusion: Preoperative treatment with dexamethasone and dipyrone but not dipyrone alone prevents sensory hypersensitivity following third molar extraction.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Anti-Inflammatory Agents / administration & dosage*
  • Cranial Nerve Injuries / etiology
  • Cranial Nerve Injuries / physiopathology
  • Dexamethasone / administration & dosage*
  • Dipyrone / administration & dosage*
  • Electric Stimulation
  • Female
  • Humans
  • Lingual Nerve Injuries
  • Lingual Nerve* / physiopathology*
  • Male
  • Mandibular Nerve* / physiopathology
  • Molar, Third / surgery
  • Neuritis / complications
  • Neuritis / etiology
  • Neuritis / physiopathology
  • Orbit / innervation
  • Pain Measurement
  • Pain, Postoperative / etiology
  • Pain, Postoperative / prevention & control*
  • Preoperative Care
  • Sensory Thresholds / drug effects*
  • Somatosensory Disorders / etiology
  • Somatosensory Disorders / prevention & control*
  • Tooth Extraction / adverse effects*
  • Trigeminal Nerve Injuries


  • Anti-Inflammatory Agents
  • Dipyrone
  • Dexamethasone