Synthesis and antioxidant properties of some novel benzimidazole derivatives on lipid peroxidation in the rat liver

Arch Pharm Res. 2004 Feb;27(2):156-63. doi: 10.1007/BF02980099.

Abstract

Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1H-benzimidazoles (1a-13a), N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]-thiadiazole-2-yl]-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yl-methyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (1c-13c) were synthesized, and their in vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound 10a caused an 84% inhibition of LP at 10(-3) M, which is better than that of butylated hydroxytoluene (BHT) (65%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemical synthesis*
  • Antioxidants / pharmacology*
  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / pharmacology*
  • Chemical Phenomena
  • Chemistry, Physical
  • In Vitro Techniques
  • Indicators and Reagents
  • Lipid Peroxidation / drug effects*
  • Liver / drug effects
  • Liver / metabolism*
  • Magnetic Resonance Spectroscopy
  • Male
  • Mass Spectrometry
  • NADP / metabolism
  • Rats
  • Semicarbazides / chemical synthesis
  • Semicarbazides / pharmacology
  • Spectrophotometry, Infrared
  • Thiadiazoles / chemical synthesis
  • Thiadiazoles / pharmacology
  • Triazoles / chemical synthesis
  • Triazoles / pharmacology

Substances

  • Antioxidants
  • Benzimidazoles
  • Indicators and Reagents
  • Semicarbazides
  • Thiadiazoles
  • Triazoles
  • NADP