Platelet concentrate injection improves Achilles tendon repair in rats

Acta Orthop Scand. 2004 Feb;75(1):93-9. doi: 10.1080/00016470410001708190.


Background: Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair.

Experiment and findings: We studied whether a platelet concentrate injection would improve Achilles tendon repair in an established rat model. The Achilles tendon was transected and a 3 mm segment removed. After 6 h, a platelet concentrate was injected percutaneously into the hematoma. This increased tendon callus strength and stiffness by about 30% after 1 week, which persisted for as long as 3 weeks after the injection. At this time, the mechanical testing indicated an improvement in material characteristics--i.e., greater maturation of the tendon callus. This was confirmed by blinded histological scoring.

Interpretation: Platelet concentrate may prove useful for the treatment of Achilles tendon ruptures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Achilles Tendon / injuries*
  • Achilles Tendon / pathology
  • Achilles Tendon / physiopathology*
  • Animals
  • Disease Models, Animal
  • Female
  • Injections, Intralesional
  • Male
  • Platelet Transfusion / methods*
  • Pliability
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Rupture / pathology
  • Rupture / physiopathology
  • Rupture / therapy
  • Tensile Strength / physiology
  • Wound Healing / physiology*