Development and function of CD25+CD4+ regulatory T cells

Curr Opin Immunol. 2004 Apr;16(2):203-8. doi: 10.1016/j.coi.2004.01.004.


The essential role played by CD25(+)CD4(+) regulatory T cells (T(R) cells) in the control of physiological as well as pathological immunity is now well established, but many aspects of their biology still remain unclear. One of the unresolved issues regards their development: where does this occur, what signals are required, and how do T(R) cells fit into the larger taxonomy of the T-cell family? Recent data has begun to shed light on the development and function of these important cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / physiology*
  • DNA-Binding Proteins / physiology
  • Forkhead Transcription Factors
  • Gene Expression Regulation, Developmental
  • Humans
  • Mice
  • Models, Biological
  • Receptors, Interleukin-2 / physiology*
  • Self Tolerance / immunology
  • Signal Transduction
  • Thymus Gland / cytology
  • Thymus Gland / immunology


  • DNA-Binding Proteins
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Foxp3 protein, mouse
  • Receptors, Interleukin-2