Decreased 5-HT1A receptor binding in amygdala of schizophrenia

Biol Psychiatry. 2004 Mar 1;55(5):439-44. doi: 10.1016/j.biopsych.2003.11.016.


Background: On the basis of postmortem data and the pharmacological action of atypical antipsychotics, serotonin-1A receptors are of interest in the study of the pathophysiology of schizophrenia. To investigate serotonin-1A receptors in schizophrenia and their relation to symptoms, we measured the availability of serotonin-1A receptors in patients with schizophrenia using positron emission tomography with [carbonyl-(11)C]WAY-100635.

Methods: Serotonin-1A receptor binding of 11 patients with schizophrenia (8 drug-naive and 3 drug-free) was compared with that of 22 age-matched and gender-matched healthy control subjects. Symptoms were assessed using the Positive and Negative Syndrome Scale. Serotonin-1A receptor binding in selected regions of interest was quantified by binding potential obtained by the reference tissue method.

Results: The regional binding potential value was lower in the amygdala by about 19% in patients with schizophrenia than in normal controls. A significant negative correlation was observed between binding potential in the amygdala and the negative and depression/anxiety symptom scores on the five-symptom subscale of the Positive and Negative Syndrome Scale.

Conclusions: Decreased serotonin-1A receptor binding in the amygdala may underlie the affective components included in the symptoms of negative and depression/anxiety in schizophrenia.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Affective Symptoms / etiology*
  • Affective Symptoms / metabolism
  • Amygdala / diagnostic imaging*
  • Amygdala / metabolism*
  • Analysis of Variance
  • Anxiety / complications
  • Anxiety / metabolism
  • Brain Mapping
  • Carbon Radioisotopes
  • Depression / complications
  • Depression / metabolism
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Matched-Pair Analysis
  • Neuropsychological Tests
  • Piperazines
  • Pyridines
  • Receptor, Serotonin, 5-HT1A / metabolism*
  • Schizophrenia / complications*
  • Schizophrenia / diagnostic imaging
  • Schizophrenia / metabolism*
  • Serotonin Antagonists
  • Tomography, Emission-Computed


  • Carbon Radioisotopes
  • Piperazines
  • Pyridines
  • Serotonin Antagonists
  • Receptor, Serotonin, 5-HT1A
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide