Isopropyl Amide Derivatives of Potent and Selective Muscarinic M2 Receptor Antagonists

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1791-4. doi: 10.1016/j.bmcl.2004.01.033.

Abstract

Low molecular weight amide derivatives were synthesized and evaluated as M(2) receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M(2) receptor antagonists with structural features different from our clinical candidate 1.

MeSH terms

  • Amides / chemical synthesis*
  • Humans
  • Muscarinic Antagonists / chemical synthesis
  • Muscarinic Antagonists / chemistry*
  • Muscarinic Antagonists / metabolism*
  • Protein Binding / physiology
  • Receptor, Muscarinic M2 / antagonists & inhibitors*
  • Receptor, Muscarinic M2 / metabolism*

Substances

  • Amides
  • Muscarinic Antagonists
  • Receptor, Muscarinic M2