Review
doi: 10.1016/0968-0004(92)90404-w.
The ets gene family
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- PMID: 1502727
- DOI: 10.1016/0968-0004(92)90404-w
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Review
The ets gene family
Trends Biochem Sci.
1992 Jul.
Abstract
Ets proteins have a conserved DNA-binding domain and regulate transcriptional initiation from a variety of cellular and viral gene promoter and enhancer elements. Some members of the Ets family, Ets-1 and Ets-2, cooperate in transcription with the AP-1 transcription factor, the product of the proto-oncogene families, fos and jun, while others, Elk-1 and SAP-1, form ternary complexes with the serum response factor (SRF). Certain ets gene family members possess transforming activity while others are activated by proviral integration in erythroleukaemias.
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